ApoE attenuates unresolvable inflammation by complex formation with activated C1q

P94: Nigella Sativa Attenuates Neuro-Inflammation by Alleviating Periodontitis

Neuro-inflammation is a reaction to brain injury involving the activation of glial cells and release of inflammatory mediators, such as cytokines and chemokines which has a key role in neuro-degenerative diseases. Periodontitis is a microbiome-related dental inflammation caused by gram- negative bacteria that leads to connective tissue destruction and loss of teeth. Previous studies demonstrated...

Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice

INTRODUCTION Atherosclerosis is a chronic inflammatory disease characterized by endothelial cell damage, infiltration, proliferation and accumulation of macrophages, lymphocytes and transformed vascular smooth muscle cells within the vascular wall and procoagulation processes involving activation of plasmatic coagulation events and platelets. Numerous studies suggested a close interaction betwe...

Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia.

The present study attempts to investigate the effect of H(2)S on lipopolysaccharide (LPS)-induced inflammation in both primary cultured microglia and immortalized murine BV-2 microglial cells. We found that exogenous application of sodium hydrosulfide (NaHS) (a H(2)S donor, 10-300 micro mol/L) attenuated LPS-stimulated nitric oxide (NO) in a concentration-dependent manner. Stimulating endogenou...

ApoE attenuates atherosclerosis via miR-146a.

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia*s⃞

Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR agonists have been shown to limit the cellular cholesterol content by inducing reverse cholesterol transport, increasing bile acid production, and inhibiting intestinal cholesterol absorption. Most of them, however, also increase lipogenesis via sterol regulatory element-binding protein-1c (SREBP1c) and c...